Novel Leptin-Regulated Genes Revealed by Transcriptional Profiling of the Hypothalamic Paraventricular Nucleus

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Novel leptin-regulated genes revealed by transcriptional profiling of the hypothalamic paraventricular nucleus.

Leptin plays a major role in coordinating the integrated response of the CNS to changes in nutritional state. Neurons within the paraventricular nucleus (PVN) of the hypothalamus express leptin receptors and receive dense innervation from leptin receptor-expressing neurons in the arcuate nucleus. To obtain new insights into the effects of circulating leptin on PVN function, we compared global t...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2008

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.3412-08.2008